姓 名：康彦彪 教授 博导 电 话： 0551-63603693 电子邮件： ybkang@ustc.edu.cn 传 真： 主页：http://team.ustc.edu.cn/kanglab |  | |
个人简历 2012-至今中国科学技术大学化学系：博导、特任研究员、教授 2008-2012德国海德堡大学：洪堡学者、博士后 2007-2008 美国Brandeis大学：博士后 2002-2007 中国科学院上海有机化学研究所：博士 1998-2002 南京大学化学化工学院：学士
主要研究方向 1. 面向工业化的选择性清洁氧化反应。 1. 前沿手性催化与合成。 2. 基于化学反应动力学的有机反应机理研究。 4. 新型聚合材料新型聚合方法。
经费支持和荣誉 (1) 国家重点研发计划“催化科学”(2021YFA1500100) (参与，130万) (2)国家优秀青年科学基金(2019) (3) 国家自然科学基金NSFC (主持21672196, 21404096, 21922109; 参与U1463202, 21831007) (4) 中科院先导B专项经费 (XDB20020100, 参与) (5) Thieme Chemistry Journals Award (2018) (6) 张宗植青年教师奖 (2016) (7) ACS Membership Award (3-year) (2015) (8) 国家自然科学奖（二等奖），2012（排名第五） (9) 洪堡奖学金，亚历山大.冯.洪堡基金会，2007
论文发表： ORCID: http://orcid.org/0000-0002-7537-4627 本课题组一直致力于独具特色的前沿和应用兼顾的基础研究，在基础性科学问题方面取得有意义的发现或发展，尤其是基于有机反应动力学的反应机理探索方面取得诸多发现，并且在实用性合成新方法方面取得系列成果。新反应可以应用在二十多种药物或活性分子的大量制备中。近年发表通讯作者研究论文五十来篇，包括J. Am. Chem. Soc.3篇，Angew. Chem.1篇，Nat. Commun. 1篇，ACS Catal.1篇，Org. Lett.22篇，Chem. Commun.3篇等。部分工作多次被Synfacts以及有机化学网站Organic Chemistry Portal给予积极评述。 (1) Zi-Hong Luan, Jian-Ping Qu, Yan-Biao Kang*, Discovery of Oxygen α-Nucleophilic Addition to α,β-Unsaturated Amides Catalyzed by Redox-Neutral Organic Photoreductant, J. Am. Chem. Soc.2020, 142, 20942-20947: https://pubs.acs.org/doi/10.1021/jacs.0c10707. (2) Peng-Fei Dai, Xiao-Shan Ning, Hua Wang, Xian-Chao Cui, Jie Liu, Jian-Ping Qu*, Yan-Biao Kang*, Cleavage Of C(Aryl)-Ch3 Bonds in The Absence of Directing Groups under Transition Metal Free Conditions,Angew. Chem. Int. Ed. 2019, 58, 5392.(VIP paper, Highlighted by Paul Knochel in Synfacts 2019, 12, 0556): https://doi.org/10.1002/anie.201901783. (3) Xiang-Huan Shan, Hong-Xing Zheng, Bo Yang, Lin Tie, Jia-Le Fu, Jian-Ping Qu*, Yan-Biao Kang*, Copper-Catalyzed Oxidative Benzylic C-H Cyclization via Iminyl Radical from Intermolecular Anion-Radical Redox Relay,Nat. Commun.2019, 10, 908: https://doi.org/10.1038/s41467-019-08849-z. (4) Jie Liu, Hong-Xing Zheng, Chuan-Zhi Yao, Bing-Feng Sun, Yan-Biao Kang*,Pharmaceutical-Oriented Selective Synthesis of Mononitriles and Dinitriles Directly From Methyl(Hetero)Arenes: Access to Chiral Nitriles and Citalopram,J. Am. Chem. Soc.2016, 138, 3294. (Highlighted by Kocienski in Synfacts 2016, 12, 0556): https://doi.org/10.1021/jacs.6b00180. (5) Mei-Mei Wang, Xiao-Shan Ning, Jian-Ping Qu*, Yan-Biao Kang*, Dehydrogenative Synthesis of Linear α,β-Unsaturated Aldehydes with Oxygen at Room Temperature Enabled by tBuONO, ACS Catal.2017, 7, 4000-4003: https://doi.org/10.1021/acscatal.7b01008. (6) Hua Wang, Jian-Ping Qu, Yan-Biao Kang*, CBZ6 as a Recyclable Organic Photoreductant for Pinacol Coupling, Org. Lett.2021, 23, 8, 2900–2903。 (7) Xiao-Wei Zhang, Guo-Qing Jiang, Shu-Hui Lei, Xiang-Huan Shan, Jian-Ping Qu*, Yan-Biao Kang*, Iron-Catalyzed α,β-Dehydrogenation of Carbonyl Compounds, Org. Lett.2021, 23, 1611–1615. (8) Shu-Hui Lei, Ya Zhong, Xian-Peng Cai, Qing Huang, Jian-Ping Qu*, Yan-Biao Kang*,Direct Synthesis of β-Amino Aldehydes from Linear Allylic Esters Using O2 as the Sole Oxidant, Org. Lett.2021, 23, 9273−9276. (9) Peng-Fei Dai, Yi-Ping Wang, Jian-Ping Qu*, and Yan-Biao Kang*, tert-Butyl Nitrite as a Twofold Hydrogen Abstractor for Dehydrogenative Coupling of Aldehydes with N-Hydroxyimides, Org. Lett.2021, 23, 9360–9364. (10) Shu-Hui Lei, Ya Zhong, Xian-Peng Cai, Qing Huang, Jian-Ping Qu*,Yan-Biao Kang*, Direct Synthesis β-Acyloxy Aldehydes from Linear Allylic Esters Using O2 as Sole Oxidant, Org. Chem. Front., 2021, 8, 2981-2984. (11) Lin Tie, Xiang-Huan Shan, Jian-Ping Qu*,Yan-Biao Kang*, α-Trideuteration of methylarenes, Org. Chem. Front., 2021, 8, 2981-2984. (12) Ya-Wei Li, Hong-Xing Zheng, Bo Yang, Xiang-Huan Shan, Jian-Ping Qu*, Yan-Biao Kang*, tBuOK-Promoted Cyclization of Imines with Aryl Halides, Org. Lett.2020, 22, 4553–4556: https://doi.org/10.1021/acs.orglett.0c01615. (13) Qing Huang, Ya-Wei Li, Xiao-Shan Ning, Guo-Qing Jiang, Xiao-Wei Zhang, Jian-Ping Qu,* Yan-Biao Kang*, Regioselective Wacker-Type Oxidation of Internal Olefins in tBuOH Using Oxygen as the Sole Oxidant and tBuONO as the Organic Redox Cocatalyst, Org. Lett.2020, 22, 965-969: https://doi.org/10.1021/acs.orglett.9b04503. (14) Xiang-Huan Shan,# Mei-Mei Wang,# Lin Tie, Jian-Ping Qu, Yan-Biao Kang*, CuSO4‑Catalyzed Tandem C(sp3)−H Insertion Cyclization of Toluenes with Isonitriles to Form Indoles, Org. Lett.2020, 22, 357-360: https://doi.org/10.1021/acs.orglett.9b03751. (15) Ting-Hui Ding, Jian-Ping Qu,* Yan-Biao Kang* Visible-Light-Induced, Base-Promoted Transition-Metal-Free Dehalogenation of Aryl Fluorides, Chlorides, Bromides, and Iodides, Org. Lett.2020, 22, 3084–3088: https://doi.org/10.1021/acs.orglett.0c00827. (16) Peng-Fei Dai, Jian-Ping Qu,* Yan-Biao Kang*, Organocatalyzed Aerobic Oxidation of Aldehydes to Acids, Org. Lett. 2019, 21, 1393-1396: https://doi.org/10.1021/acs.orglett.9b00101. (17) Xiang-Huan Shan, Bo Yang, Hong-Xing Zheng, Jian-Ping Qu*, Yan-Biao Kang*, Phenanthroline‑tBuOK Promoted Intramolecular C−H Arylation of Indoles with ArI under Transition-Metal-Free Conditions, Org. Lett. 2018, 20, 7898-7901: https://doi.org/10.1021/acs.orglett.8b03449. (18) Hong-Xing Zheng, Xiang-Huan Shan, Jian-Ping Qu*, Yan-Biao Kang*,Strategy for Overcoming Full Reversibility of Intermolecular Radical Addition to Aldehydes: Tandem C−H and C−O Bonds Cleaving Cyclization of (Phenoxymethyl)arenes with Carbonyls to Benzofurans, Org. Lett. 2018, 20, 3310-3313: https://doi.org/10.1021/acs.orglett.8b01207. (19) Zu-Feng Xiao, Ting-Hui Ding, Sheng-Wei Mao, Zaher Shah, Xiao-Shan Ning, Yan-Biao Kang*, Iridium-Catalyzed Cyclization of Isoxazolines and Alkenes: Divergent Access to Pyrrolidines, Pyrroles, and Carbazoles, Org. Lett. 2016, 18, 5672-5675. (Highlighted by Snieckus & Trujillo in Synfacts 2017, 13, 0023): https://doi.org/10.1021/acs.orglett.6b02905. (20) Hong-Xing Zheng,# Xiang-Huan Shan,# Jian-Ping Qu*, Yan-Biao Kang*, Transition-Metal-Free Hydrogenation of Aryl Halides: From Alcohol to Aldehyde, Org. Lett. 2017, 19, 5114-5117: https://doi.org/10.1021/acs.orglett.7b02399. (21) Xiao-Shan Ning, Mei-Mei Wang, Chuan-Zhi Yao, Xian-Min Chen, Yan-Biao Kang*,tert-Butyl Nitrite: Organic Redox Cocatalyst for Aerobic Aldehyde-Selective Wacker-Tsuji Oxidation,Org. Lett.2016, 18, 2700-2703: https://doi.org/10.1021/acs.orglett.6b01165. (22) Jie Liu, Kang-Fei Hu, Jian-Ping Qu*, Yan-Biao Kang*, Organopromoted Selectivity-Switchable Synthesis of Polyketones, Org. Lett. 2017, 19, 5593-5596: https://doi.org/10.1021/acs.orglett.7b02731. (23) Jing-Jie Ge,# Chuan-Zhi Yao,# Mei-Mei Wang, Hong-Xing Zheng, Yan-Biao Kang*, Yadong Li, Transition-Metal-Free Deacylative Cleavage of Unstrained C(sp3)-C(sp2) Bonds: Cyanide-Free Access to Aryl and Aliphatic Nitriles from Ketones and Aldehydes, Org. Lett.2016, 18, 228-231: https://doi.org/10.1021/acs.orglett.5b03367. (24) Xian-Min Chen, Xiao-Shan Ning, Yan-Biao Kang*, Aerobic Acetoxyhydroxylation of Alkenes Co-catalyzed by Organic Nitrite and Palladium, Org. Lett. 2016, 18, 5368-5371: https://doi.org/10.1021/acs.orglett.6b02743. (25) Qiang-Qiang Li, Zu-Feng Xiao, Chuan-Zhi Yao, Hong-Xing Zheng, Yan-Biao Kang*, Direct Alkylation of Amines with Alcohols Catalyzed by Base, Org. Lett.2015, 17, 5328-5331: https://doi.org/10.1021/acs.orglett.5b02685. (26) Hong-Xing Zheng, Zu-Feng Xiao, Chuan-Zhi Yao, Qiang-Qiang Li, Xiao-Shan, Ning, Yan-Biao Kang*, Yong Tang, Transition-Metal-Free Self-Hydrogen-Transferring Allylic Isomerization, Org. Lett.2015, 17, 6102-6105: https://doi.org/10.1021/acs.orglett.5b03124. (27) Zu-Feng Xiao, Chuan-Zhi Yao, Yan-Biao Kang*, Ruthenium-Catalyzed Asymmetric N‑Demethylative Rearrangement of Isoxazolidines and Its Application in the Asymmetric Total Syntheses of (-)-(1R,3S)‑HPA-12 and (+)-(1S,3R)‑HPA-12, Org. Lett.2014, 16, 6512-6514: https://doi.org/10.1021/ol503261h. (28) Chuan-Zhi Yao, Zu-Feng Xiao, Xiao-Shan Ning, Jie Liu, Xiao-Wei Zhang, Yan-Biao Kang*, Synthesis of syn-1,3-Aminoalcohols via a Ru-Catalyzed N‑Demethylative Rearrangement of Isoxazolidines and Its Application in a Three-Step Total Synthesis of HPA-12, Org. Lett.2014, 16, 5824-5826: https://doi.org/10.1021/ol502956j. (29) Chuan-Zhi Yao, Zu-Feng Xiao, Jie Liu, Xiao-Shan Ning, Yan-Biao Kang*, Ru-Catalyzed Rearrangement of N‑Methyl Isoxazolidines to N-H 1,3‑Oxazinanes: A Strategy of Self-Hydride Transferring Cleavage of N-O Bonds, Org. Lett.2014, 16, 2498-2501: https://doi.org/10.1021/ol500869p. (30) Xiang-Huan Shan,# Bo Yang,# Jian-Ping Qu, Yan-Biao Kang*, CuSO4-Catalyzed Dual Annulation to Synthesize O, S or N-Containing Tetracyclic Heteroacenes, Chem. Commun. 2020,56, 4063-4066: https://doi.org/10.1039/d0cc01172j. (31) Yan-Biao Kang,* Xian-Min Chen, Chuan-Zhi Yao, Xiao-Shan Ning, Direct Oxidative Lactonization of Alkenoic Acids Mediated Solely by NaIO4: Beyond A Simple Oxidant, Chem. Commun. 2016, 52, 6193-6196: https://doi.org/10.1039/c6cc02246d. (32) Chuan-Zhi Yao, Qiang-Qiang Li, Mei-Mei Wang, Xiao-Shan Ning, Yan-Biao Kang*, (E)-Specific Direct Julia-Olefination of Aryl Alcohols without Extra Reducing Agents Promoted by Bases, Chem. Commun. 2015, 51, 7729-7732: https://doi.org/10.1039/c5cc01965f. (33) Peng-Fei Dai, Hua Wang, Xian-Chao Cui, Jian-Ping Qu*, Yan-Biao Kang*, Recent Progress in C(aryl)–C(alkyl) Bond Cleavage of Alkylarenes, Org. Chem. Front., 2020, 7, 820–828: https://doi.org/10.1039/C9QO01438A. (34) Hong-Xing Zheng,# Chuan-Zhi Yao,# Jian-Ping Qu*, Yan-Biao Kang*, nBu4NOTf-promoted Radical Self-Hydrogen Transferring Isomerization under Transition Metal-Free Conditions, Org. Chem. Front. 2018, 5, 1213-1216: https://doi.org/10.1039/c7qo01138e. (35) Hong-Xing Zheng, Jian-Ping Qu*, Yan-Biao Kang*, One-pot One-base Conditions for Two Shots: Organocatalyzed Tandem Isomerization–Olefination of Allylic Alcohols, Org. Chem. Front. 2018, 5, 2349-2352: https://doi.org/10.1039/c8qo00505b. (36) Yan-Jun Zhuang, Jian-Ping Qu, Yan-Biao Kang*,Deprotonated Salicylaldehyde as Visible Light Photocatalyst, J. Org. Chem.2020, 85, 4386-4397: https://doi.org/10.1021/acs.joc.0c00102. (37) Hua Wang, Jie Liu, Jian-Ping Qu,* Yan-Biao Kang*, Overcoming Electron-Withdrawing and Product-Inhibition Effects by Organocatalytic Aerobic Oxidation of Alkylpyridines and Related Alkylheteroarenes to Ketones, J. Org. Chem. 2020, 85, 3942-3948: https://doi.org/10.1021/acs.joc.9b03205. (38) Yi-Jie Niu,# Guo-Hui Sui,# Hong-Xing Zheng, Xiang-Huan Shan, Lin Tie, Jia-Le Fu, Jian-Ping Qu*, Yan-Biao Kang*, Competing Dehalogenation versus Borylation of Aryl Iodides and Bromides under Transition-Metal-Free Basic Conditions, J. Org. Chem.2019, 84, 10805-10813: https://doi.org/10.1021/acs.joc.9b01350. (39) Mei-Mei Wang, Guo-Hui Sui, Xian-Chao Cui, Hui Wang, Jian-Ping Qu*, Yan-Biao Kang*, Radical α,β-Dehydrogenation of Saturated Amides via α‑Oxidation with TEMPO under Transition Metal-Free Conditions, J. Org. Chem.2019, 84, 8267-8274: https://doi.org/10.1021/acs.joc.9b00872. (40) Kang-Fei Hu,# Xiao-Shan Ning,# Jian-Ping Qu*, Yan-Biao Kang*, Tuning Regioselectivity of Wacker Oxidation in One Catalytic System: Small Change Makes Big Step, J. Org. Chem.2018, 83, 11327-11332: https://doi.org/10.1021/acs.joc.8b01547. (41) Qiang-Qiang Li, Zaher Shah, Jian-Ping Qu*, Yan-Biao Kang*, Direct Wittig Olefination of Alcohols, J. Org. Chem.2018, 83, 296-302: https://doi.org/10.1021/acs.joc.7b02720. (42) Ting-Hui Ding, Zu-Feng Xiao, Jian-Ping Qu*, Yan-Biao Kang*,Synthesis of Highly Functionalized Indoles and Indolones via Selectivity-Switchable Olefinations, J. Org. Chem.2018, 83, 2467-2472: https://doi.org/10.1021/acs.joc.7b03158. (43) Xiao-Shan Ning, Mei-Mei Wang, Jian-Ping Qu*, Yan-Biao Kang*, Synthesis of Functionalized Indoles via Palladium-Catalyzed Aerobic Cycloisomerization of o‑Allylanilines Using Organic Redox Cocatalyst, J. Org. Chem.2018, 83, 13523-13529: https://doi.org/10.1021/acs.joc.8b01999. (44) Xiao-Shan Ning, Xin Liang, Kang-Fei Hu, Chuan-Zhi Yao, Jian-Ping Qu*, Yan-Biao Kang*, Pd-tBuONO Cocatalyzed Aerobic Indole SynthesisAdv. Synth. Catal.2018, 360, 1590-1594: https://doi.org/10.1002/adsc.201701512. (45) Zu-Feng Xiao, Ting-Hui Ding, Sheng-Wei Mao, Xiao-Shan Ning, Yan-Biao Kang*, Zinc Iodide-Mediated Direct Synthesis of 2,3-Dihydroisoxazoles from Alkynes and Nitrones, Adv. Synth. Catal.2016, 358, 1859-1863: https://doi.org/10.1002/adsc.201600044. (46) Xiao-Wei Zhang, Zu-Feng Xiao, Yan-Jun Zhuang, Mei-Mei Wang, Yan-Biao Kang*, Metal-Free Autoxidative Nitrooxylation of Alkenyl Oximes with Molecular Oxygen,Adv. Synth. Catal.2016, 358, 1942-1945: https://doi.org/10.1002/adsc.201600147. (47) Xiao-Wei Zhang, Zu-Feng Xiao, Mei-Mei Wang, Yan-Jun Zhuang, Yan-Biao Kang*, Transition-Metal-Free Oxychlorination of Alkenyl Oximes: in Situ Generated Radicals with tert-Butyl Nitrite, Org. Biomol. Chem.2016, 14, 7275-7281: https://doi.org/10.1039/c6ob01374k. (48) Yan-Jun Zhuang, Jie Liu, Yan-Biao Kang*, Tin or Gallium-Catalyzed Cyanide-Transition Metal-Free Synthesis of Nitriles from Aldehydes or Oximes, Tetrahedron Lett. 2016, 57, 5700-5702: https://doi.org/10.1016/j.tetlet.2016.11.034. (49) Xiao-Shan Ning, Xue-Jiao Dong, Zu-Feng Xiao, Chuan-Zhi Yao, Yan-Biao Kang*, Ion-Pair-Catalyzed Sodium Borohydride Reduction in Aprotic Organic Solvents, Asian J. Org. Chem.2015, 4, 333-336: https://doi.org/10.1002/ajoc.201402281. (50) Palladium-Catalyzed Intramolecular Asymmetric C–H Functionalization/Cyclization Reaction of Metallocenes: An Efficient Approach toward the Synthesis of Planar Chiral Metallocene Compounds, Ruixian Deng, Yunze Huang, Xinna Ma, Gencheng Li, Rui Zhu, Bin Wang, Yan-Biao Kang,* Zhenhua Gu*, J. Am. Chem. Soc.2014, 136, 4472. (51) Jiying Pei, Yanbiao Kang* Guangming Huang*, Reactive Intermediate Detection in Real Time via Paper Assisted Thermal Ionization Mass Spectrometry, Analyst2014, 139, 5354-5357.
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