姓 名：刘扬中 教授 博导 电 话： 0551－63600874 电子邮件： liuyz@ustc.edu.cn 传 真：0551－63600874 |  | |
| 个人简历 | ||
| Yangzhong Liu obtained his Ph.D. degree in 2002 from University of Bergen in Norway in Professor Einar Sletten’s group, studying the interaction between anticancer drugs and DNA. He pursued three years postdoctoral research at University of California from 2002 -2005 at Davis, working with Professor Gerd La Mar on the paramagnetic protein NMR. He moved to Rensselaer Polytechnic Institute and worked on multidimensional NMR on 13C/15N isotope labeled proteins with Professor Chunyu Wang. In October 2006, he returned to the Department of Chemistry at USTC, where he had worked between 1992-1998 after obtaining his master degree from the department. | ||
| 主要研究方向 | ||
| Researches in this group focus on the bio-inorganic chemistry, more specifically, the structure of biological molecules and their interaction with inorganic compounds. Currently, this group is studying the solution structure of enzyme Intein and developing their inhibitors, including metal complexes and organic compounds. Another research project in this group is about the interaction between anticancer drugs and DNA, in order to elucidate the mechanism of anticancer drugs, especially those unconventional platinum-based drugs. This study will help the design and synthesis of novel drugs. Although NMR is the emphasized tool in this group, many other techniques are employed for various research purposes, such as HPLC, ITC, SPR, and electrophoresis. All individuals are encouraged to apply/develop new methods to the research in this group. | ||
| 文章及专著 | ||
| 1. Yilin Yan, Yangzhong Liu, Mirco Sorci, Georges Belfort, Joyce W. Lustbader, Shirley ShiDu Yan, and Chunyu Wang. Surface Plasmon Resonance and Nuclear Magnetic Resonance Studies of ABAD-A? Interaction. Biochemistry. 2007, 46, 1724-1731 2. Yangzhong Liu; Li-Hua Ma; Xuhong Zhang; Tadashi Yoshida; James D. Satterlee; Gerd N. La Mar. Characterization of the spontaneous "aging" of the heme oxygenase from the pathological bacterium Nisseria meningitidis via cleavage of the C-terminus in contact with the substrate; Implications for functional studies and the crystal structure. Biochemistry 2006; 45(12); 3875-3886 3. Yangzhong Liu; Li-Hua Ma; Xuhong Zhang; Tadashi Yoshida, James D. Satterlee; Gerd N. La Mar. 1H NMR study of the influence of hemin vinyl?methyl substitution on the interaction between the C-terminus and substrate and the "aging" of the heme oxygenase from Nisseria meningitidis. Induction of active site structural heterogeneity by a two-fold symmetric hemin. Biochemistry 2006; 45(46); 13875-13888 4. Li-Hua Ma; Yangzhong Liu; Xuhong Zhang; Tadashi Yoshida; Kevin C. Langry; Kevin M. Smith, Gerd N. La Mar. Modulation of the axial water hydrogen-bonding properties by chemical modification of the substrate in resting state, substrate-bound heme oxygenase from Nisseria meningitidis; Coupling to the distal H-bond network via ordered water molecules. Journal of the American Chemical Society 2006; 128(19); 6391-6399 5. Li-Hua Ma, Yangzhong Liu, Xuhang Zhang, Tadashi Yoshida and Gerd N. La Mar. 1H NMR study of the magnetic properties and electronic structure of the hydroxide complex of substrate-bound heme oxygenase from Nisseria meningitides; Influence of the axial water deprotonation on the distal H-bond network. Journal of the American Chemical Society 2006; 128(20); 6657-6668 6. Yangzhong Liu; Xuhong Zhang; Tadashi Yoshida; Gerd N. La Mar. Solution 1H NMR characterization of the distal H-bond network and the effective axial field in the resting-state, high-spin ferric, substrate-bound complex in heme oxygenase from N. meningitidis. Journal of the American Chemical Society. 2005, 127(17) 6409-6422. 7. Yangzhong Liu; Xuhong Zhang; Tadashi Yoshida; Gerd N. La Mar. 1H NMR characterization of the solution active site structure of substrate-bound, cyanide-inhibited heme oxygenase from Neissesae meningitides. Biochemistry 2004, 43 (31) 10112-10126. 8. Yangzhong Liu; Einar Sletten. Interaction between macrocyclic nickel complexes and the nucleotides GMP, AMP, and ApG.. Journal of Inorganic Biochemistry 2003, 93(3-4), 190-196 9. Yangzhong Liu; Jo Vinje; Concetta Pacifico; Giovanni Natile; Einar Sletten. Formation of adenine-N3/guanine-N7 cross-link in the reaction of trans-oriented platinum substrates with dinucleotides. Journal of the American Chemical Society 2002, 124(43), 12854-12862 10. Liu, Yangzhong; Intini, Francesco P.; Natile, Giovanni; Sletten, Einar. Kinetic study of the reaction between an antitumor 15N labeled trans-platinum iminoether complex and GMP by [1H, 15N] HMQC NMR. Journal of the Chemical Society, Dalton Transactions 2002, (18), 3489-3495 11. Liu, Yangzhong; Pacifico, Concetta; Natile, Giovanni; Sletten, Einar. Antitumor trans platinum complexes can form cross-links with adjacent purine groups. Angewandte Chemie, International Edition. 2001, 40(7), 1226-1228 | ||